Package: simFastBOIN
Type: Package
Title: Fast Simulation of Bayesian Optimal Interval Designs for Phase I
        Trials
Version: 2.1.0
Date: 2026-10-13
Authors@R: person(given = "Gosuke",
                  family = "Homma",
                  role = c("aut", "cre"),
                  email = "my.name.is.gosuke@gmail.com",
                  comment = c(ORCID = "0000-0002-6854-5627"))
Description: Design and evaluate phase I dose-finding trials that use the
    Bayesian optimal interval (BOIN) design of Liu and Yuan (2015)
    <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision
    boundaries, to simulate trials, to estimate the dose-toxicity curve under a
    monotonicity constraint and to select the maximum tolerated dose. The
    simulation engine is written in C++ and draws one random variate per
    patient in enrollment order, which reproduces the reference implementation
    in the 'BOIN' package trial by trial for a given seed. The traditional 3+3
    design is provided as a comparator, with operating characteristics obtained
    in closed form rather than by simulation. For toxicity that is observed
    late, the time-to-event BOIN design is provided with the two estimators of
    Yuan and colleagues (2018) <doi:10.1158/1078-0432.CCR-18-0246> and Lin and
    Yuan (2020) <doi:10.1093/biostatistics/kxz007>. Patients who arrive while
    the dose escalation waits can be backfilled to lower doses with the designs
    of Zhao and colleagues (2024) <doi:10.1158/1078-0432.CCR-23-2585> and Chen
    and colleagues (2026) <doi:10.1007/s43441-026-00994-0>, the latter with
    the suspension rules of Chen and colleagues (2025)
    <doi:10.1158/1078-0432.CCR-24-3669>. Trials of two drugs given together
    are handled by the drug-combination design of Lin and Yin (2017)
    <doi:10.1177/0962280215594494>.
License: MIT + file LICENSE
Encoding: UTF-8
Depends: R (>= 3.5.0)
Imports: Iso, Rcpp (>= 1.0.0), stats, utils
LinkingTo: Rcpp
Suggests: BOIN, ggplot2 (>= 3.4.0), knitr, rmarkdown, spelling,
        testthat (>= 3.0.0)
Language: en-US
URL: https://gosukehommaex.github.io/simFastBOIN/,
        https://github.com/gosukehommaEX/simFastBOIN
BugReports: https://github.com/gosukehommaEX/simFastBOIN/issues
Config/testthat/edition: 3
VignetteBuilder: knitr
Config/roxygen2/version: 8.0.0
NeedsCompilation: yes
Packaged: 2026-10-16 08:56:23 UTC; i_lik
Author: Gosuke Homma [aut, cre] (ORCID:
    <https://orcid.org/0000-0002-6854-5627>)
Maintainer: Gosuke Homma <my.name.is.gosuke@gmail.com>
Repository: CRAN
Date/Publication: 2026-10-16 09:20:02 UTC
Built: R 4.6.1; aarch64-apple-darwin23; 2026-10-16 13:23:54 UTC; unix
Archs: simFastBOIN.so.dSYM
