# forestly <img src="man/figures/logo.png" align="right" width="120" />

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## Installation

The easiest way to get forestly is to install from CRAN:

```r
install.packages("forestly")
```

Alternatively, to use a new feature or get a bug fix,
you can install the development version of forestly from GitHub:

```r
# install.packages("remotes")
remotes::install_github("Merck/forestly")
```

## Overview

The forestly package creates interactive forest plots for clinical trial analysis & reporting.

- Safety analysis
  - Specific adverse events analysis
- Efficacy analysis (future work)
  - Subgroup analysis

<video src="https://github.com/Merck/forestly/assets/129398183/2a645ac6-86f3-42c8-bcba-1970da916fae" data-canonical-src="https://github.com/Merck/forestly/assets/129398183/2a645ac6-86f3-42c8-bcba-1970da916fae" controls="controls" muted="muted" class="d-block rounded-bottom-2 width-fit" style="max-height:640px;max-width:60%;">

</video>

We assume ADaM datasets are ready for analysis and
leverage [metalite](https://merck.github.io/metalite/) data structure to define
inputs and outputs.

## Workflow

The general workflow is:

1. `meta_forestly()` constructs input metadata for treatment analysis from ADaM datasets.
1. `prepare_ae_forestly()` prepares datasets for interactive forest plot.
1. `format_ae_forestly()` formats output layout.
1. `ae_forestly()` generates an interactive forest plot.

Here is a quick example

```r
library("forestly")

meta_forestly(
  dataset_adsl = forestly_adsl,
  dataset_adae = forestly_adae,
  parameter_term = "any;rel;ser",
  population_subset = SAFFL == "Y",
  observation_subset = SAFFL == "Y"
) |>
  prepare_ae_forestly(parameter = "any;rel;ser") |>
  format_ae_forestly() |>
  ae_forestly()
```

## Interactive features

The interactive features for safety analysis include:

- Select different AE criteria.
- Filter by incidence of AE in one or more groups.
- Reveal information by hovering the mouse over a data point.
- Search bars to find subjects with selected adverse events (AEs).
- Sort value by clicking the column header.
- Drill-down listing by clicking $\blacktriangleright$.

## References

- Paper: [2023 PHUSE US Connect](https://phuse.s3.eu-central-1.amazonaws.com/Archive/2023/Connect/US/Florida/PAP_DV07.pdf)
- Talk: [2021 R/Pharma Conference](https://rinpharma.com/publication/rinpharma_206/)
