********************************************************************************
*                        addsd_strong-monolix.mlxtran                          *
*                        September 24, 2026 at 04:26:48                        *
*                        Monolix version : 2024R1                              *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop      :                         1.57     0.309      19.8      1.07      2.28
cl_pop      :                         2.52     0.294      11.7      2.01      3.16
beta_cl_lWT :                        0.565     0.602       106    -0.614      1.74
v_pop       :                         28.4      2.76      9.74      23.5      34.3
fr_pop      :                        0.902    0.0926      10.3     0.628      0.98

Standard Deviation of the Random Effects -
omega_ka    :                        0.633     0.148      23.3     0.408     0.983
omega_cl    :                        0.249    0.0637      25.6     0.154     0.402
omega_v     :                        0.139    0.0413      29.6    0.0807     0.241

Error Model Parameters -------------------
add__sd     :                        0.698    0.0503       7.2     0.607     0.804

Elapsed time (seconds):       30
CPU time     (seconds):       29
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

 _______________________________________________________________________________



ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.735          1.01          1.43          2.11          6.12             2
cl :          1.58          2.14          2.61          2.91          3.65          3.62
v  :          23.4          25.5          28.6          30.9          34.5            12
fr :         0.902         0.902         0.902         0.902         0.902           nan

Elapsed time (seconds):    0.056
CPU time     (seconds):        0

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
     ka_pop         1
     cl_pop -0.052829         1
beta_cl_lWT -0.011044  0.086634         1
      v_pop  0.048653   0.56938 -0.022444         1
     fr_pop-0.0098633   0.71091 -0.016919   0.87155         1
   omega_ka  0.024562-0.0010319 -0.027242  -0.01791-0.0060798         1
   omega_cl -0.025588  0.090687  0.072316  0.020402   0.05114 -0.018598         1
    omega_v  0.053501  -0.16415  -0.11749  -0.10165  -0.15352  0.061018  -0.22728         1
    add__sd -0.016305  -0.01997  0.035523 -0.029058 -0.032664 -0.067364-0.0077433 -0.041108         1

                               min       max   max/min
Eigen values           :       0.1       2.5        24

Elapsed time (seconds):      5.1
CPU time     (seconds):      5.1
Iterations:      100 (Autostop)

 -------------------------------------------------------------------------------

 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         359.88
Akaike Information Criteria               (AIC) :         377.88
Corrected Bayesian Information Criteria  (BICc) :         394.23
Bayesian Information Criteria             (BIC) :         382.24

Elapsed time                          (seconds) :           4.41
CPU time                              (seconds) :           4.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.037
                      Sampling distribution : T-distribution with 5 degrees of freedom

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 132
Number of doses: 12

