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*                        beta_strong-monolix.mlxtran                           *
*                        September 24, 2026 at 04:25:59                        *
*                        Monolix version : 2024R1                              *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop      :                         1.57     0.316      20.1      1.07      2.31
cl_pop      :                         2.35     0.346      14.7      1.77      3.12
beta_cl_lWT :                         0.75     0.616      82.1    -0.457      1.96
v_pop       :                         26.4      3.18        12      20.9      33.3
fr_pop      :                        0.838     0.102      12.1     0.564     0.954

Standard Deviation of the Random Effects -
omega_ka    :                        0.644     0.159      24.6     0.405      1.02
omega_cl    :                        0.251    0.0654      26.1     0.154     0.408
omega_v     :                        0.141    0.0429      30.4    0.0805     0.247

Error Model Parameters -------------------
add__sd     :                        0.699    0.0536      7.66     0.602     0.812

Elapsed time (seconds):       30
CPU time     (seconds):       29
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.735             1          1.43          2.11          6.15          3.44
cl :          1.48          1.98          2.44           2.7          3.42          3.72
v  :          21.8          23.7          26.6          28.7            32          13.1
fr :         0.838         0.838         0.838         0.838         0.838           nan

Elapsed time (seconds):    0.062
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
     ka_pop         1
     cl_pop -0.067903         1
beta_cl_lWT-0.0093325  0.091819         1
      v_pop 0.0009576   0.73191  0.016655         1
     fr_pop -0.043529   0.82759  0.017531   0.91836         1
   omega_ka  0.028958  0.031744 -0.035151  0.024144   0.03705         1
   omega_cl -0.027583   0.15669   0.19507   0.10422   0.12507-0.0094417         1
    omega_v  0.043327  -0.22219  -0.13275  -0.21721  -0.23641  0.051926  -0.22358         1
    add__sd-0.00095099  -0.27405  0.033879  -0.30685  -0.33042  -0.06938 -0.039144  0.025825         1

                               min       max   max/min
Eigen values           :     0.064       2.9        46

Elapsed time (seconds):      5.1
CPU time     (seconds):      5.1
Iterations:      100 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         360.03
Akaike Information Criteria               (AIC) :         378.03
Corrected Bayesian Information Criteria  (BICc) :         394.39
Bayesian Information Criteria             (BIC) :         382.40

Elapsed time                          (seconds) :           4.43
CPU time                              (seconds) :           4.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.037
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 132
Number of doses: 12

