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*                        ka_weak-monolix.mlxtran                               *
*                        September 24, 2026 at 04:25:18                        *
*                        Monolix version : 2024R1                              *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop      :                         1.58     0.313      19.8      1.08       2.3
cl_pop      :                         2.48     0.244      9.86      2.05         3
beta_cl_lWT :                        0.575     0.603       105    -0.607      1.76
v_pop       :                         28.1      2.01      7.16      24.4      32.3
fr_pop      :                        0.891    0.0534         6      0.75     0.957

Standard Deviation of the Random Effects -
omega_ka    :                        0.638     0.147      23.1     0.413     0.986
omega_cl    :                         0.25    0.0644      25.7     0.154     0.405
omega_v     :                        0.136    0.0386      28.4    0.0804      0.23

Error Model Parameters -------------------
add__sd     :                        0.699    0.0505      7.22     0.607     0.805

Elapsed time (seconds):       30
CPU time     (seconds):       29
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.735          1.01          1.44          2.11          6.14          2.73
cl :          1.56          2.11          2.58          2.87          3.61          3.57
v  :          23.2          25.2          28.3          30.5            34            11
fr :         0.891         0.891         0.891         0.891         0.891           nan

Elapsed time (seconds):     0.07
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
     ka_pop         1
     cl_pop -0.032309         1
beta_cl_lWT -0.004153  0.090666         1
      v_pop   0.08774   0.35895 -0.023094         1
     fr_pop  0.023121   0.56294 -0.029828    0.7631         1
   omega_ka  0.009862  0.011601 -0.024243 -0.026269-0.0019033         1
   omega_cl -0.016048 0.0087827  0.058078 -0.073708 -0.076085 -0.014136         1
    omega_v  0.022798  -0.12171  -0.10607  -0.10251  -0.13839  0.046569  -0.16958         1
    add__sd -0.013759-0.0023972  0.026439  0.023186  0.018145 -0.059395 -0.016952 -0.041602         1

                               min       max   max/min
Eigen values           :      0.19       2.2        11

Elapsed time (seconds):      2.6
CPU time     (seconds):      2.6
Iterations:       50 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         359.83
Akaike Information Criteria               (AIC) :         377.83
Corrected Bayesian Information Criteria  (BICc) :         394.19
Bayesian Information Criteria             (BIC) :         382.20

Elapsed time                          (seconds) :           4.42
CPU time                              (seconds) :           4.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.047
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 132
Number of doses: 12

