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*                        logit_strong-monolix.mlxtran                          *
*                        September 24, 2026 at 04:27:44                        *
*                        Monolix version : 2024R1                              *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop      :                         1.57     0.316      20.1      1.07      2.31
cl_pop      :                         1.68      0.31      18.5      1.18      2.39
beta_cl_lWT :                        0.551     0.642       116    -0.707      1.81
v_pop       :                         18.9      3.44      18.2      13.3      26.8
fr_pop      :                          0.6     0.097      16.2     0.397     0.774

Standard Deviation of the Random Effects -
omega_ka    :                        0.641     0.155      24.2     0.406      1.01
omega_cl    :                        0.248    0.0643        26     0.152     0.403
omega_v     :                        0.143    0.0429        30    0.0823     0.249

Error Model Parameters -------------------
add__sd     :                        0.698    0.0498      7.14     0.607     0.802

Elapsed time (seconds):       43
CPU time     (seconds):       42
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.736          1.01          1.43          2.11          6.15          2.86
cl :          1.05          1.43          1.74          1.93          2.42          3.64
v  :          15.6          16.9          19.1          20.6          23.1          12.9
fr :           0.6           0.6           0.6           0.6           0.6           nan

Elapsed time (seconds):    0.053
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
     ka_pop         1
     cl_pop   0.05526         1
beta_cl_lWT -0.044789  -0.27228         1
      v_pop   0.12267   0.84313  -0.35819         1
     fr_pop  0.094552   0.89425  -0.36798   0.96229         1
   omega_ka  0.025725 -0.088276-0.0017344  -0.09692 -0.095695         1
   omega_cl -0.013359   0.24192   -0.0264   0.19067   0.21588 -0.042412         1
    omega_v  0.035136  -0.17297 -0.049894  -0.12735  -0.15133  0.095937  -0.22853         1
    add__sd -0.021467 -0.045666  0.045682  -0.04518 -0.047205 -0.059691 -0.011646 -0.037976         1

                               min       max   max/min
Eigen values           :      0.03       3.1     1e+02

Elapsed time (seconds):      5.1
CPU time     (seconds):      5.1
Iterations:      100 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         359.89
Akaike Information Criteria               (AIC) :         377.89
Corrected Bayesian Information Criteria  (BICc) :         394.24
Bayesian Information Criteria             (BIC) :         382.25

Elapsed time                          (seconds) :           4.40
CPU time                              (seconds) :           4.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.032
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 132
Number of doses: 12

