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*                        two_priors-monolix.mlxtran                            *
*                        September 24, 2026 at 04:28:27                        *
*                        Monolix version : 2024R1                              *
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ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)   P2.5_sa  P97.5_sa
ka_pop      :                         2.99      26.2       876      0.16      55.7
cl_pop      :                            2      0.21      10.5      1.63      2.45
beta_cl_lWT :                        0.521     0.604       116    -0.662       1.7
v_pop       :                         22.9      1.67      7.29      19.9      26.4
fr_pop      :                        0.721    0.0431      5.97     0.629     0.798

Standard Deviation of the Random Effects -
omega_ka    :                        0.935       1.1       118     0.211      4.15
omega_cl    :                         0.25    0.0654      26.2     0.153     0.407
omega_v     :                        0.141    0.0412      29.2    0.0824     0.242

Error Model Parameters -------------------
add__sd     :                        0.693    0.0489      7.05     0.604     0.796

Elapsed time (seconds):       31
CPU time     (seconds):       30
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Mode --------------------
               min            Q1        median            Q3           max  shrinkage(%)
ka :         0.733          1.02          1.46           2.2          7.45          28.2
cl :          1.25          1.71          2.06          2.31          2.89          4.27
v  :          18.8          20.4          23.2          24.9          27.9          10.2
fr :         0.721         0.721         0.721         0.721         0.721           nan

Elapsed time (seconds):    0.058
CPU time     (seconds):        0

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ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Stochastic Approximation --------

Correlation Matrix :
     ka_pop         1
     cl_pop   -0.1226         1
beta_cl_lWT -0.073733  0.095425         1
      v_pop  -0.13971   0.41764 -0.012143         1
     fr_pop  -0.16988   0.62988 -0.012751    0.7631         1
   omega_ka   0.98254  -0.11734 -0.074259  -0.14966  -0.17088         1
   omega_cl -0.093512   0.07799  0.066299 -0.013154  0.010897 -0.091899         1
    omega_v   0.23731  -0.15962  -0.13729  -0.10095  -0.16296    0.2362  -0.23651         1
    add__sd -0.036031 -0.013052  0.017343  0.032699  0.017426 -0.037595 -0.022163 -0.021763         1

                               min       max   max/min
Eigen values           :     0.017       2.6   1.5e+02

Elapsed time (seconds):      2.7
CPU time     (seconds):      2.7
Iterations:       50 (Autostop)

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ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                            (is)
-2 x log-likelihood                       (OFV) :         367.14
Akaike Information Criteria               (AIC) :         385.14
Corrected Bayesian Information Criteria  (BICc) :         401.49
Bayesian Information Criteria             (BIC) :         389.50

Elapsed time                          (seconds) :           4.46
CPU time                              (seconds) :           4.00
MonteCarlo size (is):    10000 (Fixed number of iterations)


[Importance Sampling] Standard error        : 0.042
                      Sampling distribution : T-distribution with 5 degrees of freedom

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DATASET INFORMATION
Number of individuals: 12
Number of observations (DV): 132
Number of doses: 12

